Genetic variation underpins metformin response
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چکیده
منابع مشابه
Pharmacogenetic variation of SLC47A1 gene and metformin response in type2 diabetes patients
Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the pharmacokinetics of metformin were associated with glucose-lowering effect of metformin. The aim of this study was to evaluate pharmacogenetic v...
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Advances in molecular and recombinant DNA technology have led to exquisite studies in the field of genetics and the recognition in a much more specific way, through DNA sequencing, of how unique each one of us is, and the extent to which genetic variation occurs. The importance of the effects of genetic variation has been extensively studied and applied by pharmacologists in drug development an...
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Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is unknown. Recent studies have shown that human OCT1 is highly polymorphic. We investigated whether OCT...
متن کاملPharmacogenetic variation of SLC47A1 gene and metformin response in type2 diabetes patients
Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the pharmacokinetics of metformin were associated with glucose-lowering effect of metformin. The aim of this study was to evaluate pharmacogenetic v...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2016
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2016.143